At SCORE, we provide a variety of services to diagnose and treat your condition while helping you achieve a pain-free and healthy lifestyle. We pride ourselves in offering a state of the art facility, providing excellence in medical care by a professional and caring staff.

  • Alpha-2-Macroglobulin (A2M)

    What is Alpha-2-Macroglobulin?

    A2M is a major protein found in blood plasma. When isolated and injected into a joint it inactivates 3 major molecules (proteinases) that degrade cartilage cells. It is the degradation of these cells which contributes to Osteoarthritis. A2M can stop the progression of osteoarthritis by preventing cartilage breakdown and loss, which improves joint function and decreases pain. The Platelet Rich Plasma (PRP) that is injected with A2M reduces inflammation and promotes healing.

    How is A2M obtained?

    Blood is drawn in the office and spun twice in a centrifuge. The layer rich in platelets is the Platelet Rich Plasma (PRP). Additional filtration is performed from the plasma to obtain highly concentrated A2M. Both products are then injected using ultrasound or fluoroscopic guidance into the arthritic joint.

    A2M Therapy – One Stop Pain Treatment

    Highly concentrated injections of A2M along with PRP have the potential benefit of:

    • Stopping the breakdown of cartilage
    • Halting the progression of osteoarthritis by reducing cartilage loss
    • Reducing the pain caused by osteoarthritis
    • Improving joint function
    • Promoting tissue growth and supporting the restoration of affected joints


    • Joint arthritis of the:
      • Knee
      • Shoulder
      • Ankle
      • Hip
    • Spinal Facet Joints
    • Spinal Discs